Protein S Deficiency

There are three types of Hereditary Protein S Deficiency:

  • Type I: decreased Protein S activity, low levels of free Protein S, normal levels of bound Protein S
  • Type IIa - decreased Protein S activity, low levels of free Protein S, low levels of bound Protein S
  • Type IIb - decreased Protein S activity, normal levels of free Protein S, normal levels of bound Protein S

It is also possible to have an acquired deficiency of Protein S, which is seen in some cases of DIC, DVT, PE, pregnancy and liver disease and during treatment with anticoagulants such as warfarin.

Estimates

Protein S Deficiency occurs in about 1 in 20,000 people (1). Of those less than half develop thrombosis, usually between the ages of 20 and 30. Of all the inherited thrombophilic conditions, it remains the most difficult to diagnose (2).

Number of People in the UK with Protein S Deficiency:

  • 1 in 20,000 of UK population (60m) -> 3000

Number of UK Cases of Protein S Deficiency With Thrombophilia:

  • 3000 with PSD -> 2500 over 20 yrs old -> 40% affected -> 1000

References

  1. Medline Plus: www.nlm.nih.gov
  2. Blood, Vol. 95, No. 6, 2000, Makris et al: www.bloodjournal.org

http://www.protein.org.uk/psd.php
Last updated: Tuesday, 12th June 2007, © 2000-2008

  • Valid HTML 4.01 Strict
  • Valid CSS!
  • Level Triple-A conformance icon, W3C-WAI Web Content Accessibility Guidelines 1.0
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health
information:
verify here.

Disclaimer: For your own health and safety you should always seek the advice of a qualified medical practitioner and not act on information published on this web site. No responsibility can be accepted for the content or absence of content published on this site for any reason.